Pre-processing and QC - brain structure data:
Outliers removed (>5 SD)
Global DTI measures calculated using PCA
| Models: |
| - GLM for unilatearal brain phenotypes - LME for bilateral brain phenotypes where measures of hemisphere were treated as repeated measures - No hemishphere interactions on association between DNAm score and bilateral phenotype observed |
| Covariates: - Sex - Age - Age^2 - BMI - UKB imaging assessment centre - ICV (only for measures of brain volume) |
| Multiple comparision correction: FDR - n = number of brain structure phenotypes per imaging subcategory |
| ### Number of UKB participants with full data |
(list_df)
## [[1]]
## # A tibble: 4 × 2
## # Groups: comorbidity_group [4]
## comorbidity_group n
## <chr> <int>
## 1 No Probable Recurrent MDD + Chronic Pain 5169
## 2 No Probable Recurrent MDD + No Chronic Pain 11516
## 3 Probable Recurrent MDD + Chronic Pain 2855
## 4 Probable Recurrent MDD + No Chronic Pain 2999
##
## [[2]]
## # A tibble: 2 × 2
## # Groups: chronic_pain [2]
## chronic_pain n
## <dbl> <int>
## 1 0 23557
## 2 1 13542
##
## [[3]]
## # A tibble: 2 × 2
## # Groups: recurrent_depression [2]
## recurrent_depression n
## <int> <int>
## 1 0 16783
## 2 1 5900
## merging atlas and data by 'region'
## merging atlas and data by 'region'
## merging atlas and data by 'region'
## merging atlas and data by 'region'