Association of chronic pain and depression with brain structure

—————————————————————————————————————————-

Associations between DNAm scores and brain structure data

Models:

- GLM for unilatearal brain phenotypes - LME for bilateral brain phenotypes where measures of hemisphere were treated as repeated measures - No hemishphere interactions on association between DNAm score and bilateral phenotype observed

Covariates: - Sex - Age - Age^2 - BMI - UKB imaging assessment centre - ICV (only for measures of brain volume)

Multiple comparision correction: FDR - n = number of brain structure phenotypes per imaging subcategory

### Number of UKB participants with full data

(list_df)

## [[1]]
## # A tibble: 4 × 2
## # Groups:   comorbidity_group [4]
##   comorbidity_group                               n
##   <chr>                                       <int>
## 1 No Probable Recurrent MDD + Chronic Pain     5169
## 2 No Probable Recurrent MDD + No Chronic Pain 11516
## 3 Probable Recurrent MDD + Chronic Pain        2855
## 4 Probable Recurrent MDD + No Chronic Pain     2999
## 
## [[2]]
## # A tibble: 2 × 2
## # Groups:   chronic_pain [2]
##   chronic_pain     n
##          <dbl> <int>
## 1            0 23557
## 2            1 13542
## 
## [[3]]
## # A tibble: 2 × 2
## # Groups:   recurrent_depression [2]
##   recurrent_depression     n
##                  <int> <int>
## 1                    0 16783
## 2                    1  5900

Results - Brain structures

Effect size graph - Chronic pain status in full sample

Effect size graph - Chronic pain status in sex-stratified samples

Effect size graph - Probable Recurrent Major Depressive Disorder in full smaple

Effect size graph - Probable Recurrent Major Depressive Disorder in sex-stratified sample

Effect size graph - Comorbidity in full sample

Effect size graph - Comorbidity in female sample

Effect size graph - Comorbidity in male sample

P-value graph - Depression - full sample

P-value graph - Depression - sex-stratified sample

P-value graph - Chronic Pain Status - full sample

P-value graph - Chronic Pain - sex-stratified sample

Cortex volume map

## merging atlas and data by 'region'

Cortex area map

## merging atlas and data by 'region'

Cortex thickness map

## merging atlas and data by 'region'

Subcortex volume map

## merging atlas and data by 'region'